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KMID : 0363320000210020291
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 2 p.291 ~ p.297
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Screening for Various Herb Medicines Extracts HSV 1-2
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Lim Seong-Woo
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Abstract
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Objective : In order to find antiviral compounds against Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, a convenient virus-induced cytopathic effect(CPE) inhibition assay was introduced.
Methods : Fourteen purchased herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast.
Results : Cytotoxic concentration (CC) of the extracts of Hyongbangpaedoksan against HSV-1 and HSV-2 was 181.12. This is high level cytotoxic concentration compared with the contrast. Therefore, we assumed that the high level cytotoxic concentration of herbal medicine play a major role in improvement of antiviral activity at the first infective cell. But antiviral effect was unable to figure out for selective index(Sl)=CC50/EC50. The other herbal medicines were unable to showed potent anti-HSV activity.
Conclusions : The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.
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KEYWORD
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Herb medicine, herpes simplex virus, cytopathic effect, screening
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